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Biochemistry Internship Topics

Browse all focused areas across all internship categories under this field.

Biochemistry Internships with Accommodation

Choose an internship topic, then explore accommodation-enabled internship options at active NTHRYS branch locations in India.

Showing 13–20 of 20 internship topics
Pharmacokinetic Parameter Estimation & ADME Modeling
Interns will perform absorption, distribution, metabolism, and excretion (ADME) studies to calculate key pharmacokinetic parameters such as clearance, half-life, and volume of distribution. They will develop predictive models using non-compartmental and compartmental analysis software.
Drug Metabolism & Pharmacokinetics ResearchView internship →
Drug-Drug Interaction & CYP450 Inhibition Studies
Interns will investigate inhibitory and inductive effects of drugs on cytochrome P450 enzymes and their clinical implications. They will conduct substrate depletion assays and mechanistic studies to predict potential drug-drug interactions in polypharmacy scenarios.
Drug Metabolism & Pharmacokinetics ResearchView internship →
Metabolite Identification & Toxicology Assessment
Interns will characterize drug metabolites using tandem mass spectrometry and NMR spectroscopy to elucidate metabolic pathways. They will evaluate the toxicological potential of major metabolites and assess their contribution to overall drug safety profiles.
Drug Metabolism & Pharmacokinetics ResearchView internship →
Base Excision Repair (BER) Enzyme Kinetics
Interns will characterize the catalytic properties of BER enzymes through steady-state and pre-steady-state kinetic analyses. This involves performing enzyme assays, analyzing reaction rates, and determining Km and Vmax values using substrate analogues and damaged DNA templates.
DNA Repair Enzyme CharacterizationView internship →
Nucleotide Excision Repair (NER) Protein-DNA Interactions
Interns will investigate binding affinities and structural interactions between NER proteins and damaged DNA using techniques such as electrophoretic mobility shift assays (EMSA), surface plasmon resonance (SPR), and fluorescence spectroscopy. This work focuses on understanding substrate recognition mechanisms.
DNA Repair Enzyme CharacterizationView internship →
Mismatch Repair (MMR) Enzyme Expression and Purification
Interns will develop and optimize protocols for heterologous expression and purification of MMR enzymes (MutS, MutL homologues) in bacterial systems. They will characterize protein purity, stability, and functionality through SDS-PAGE, mass spectrometry, and biochemical assays.
DNA Repair Enzyme CharacterizationView internship →
DNA Polymerase Fidelity in Repair Pathways
Interns will evaluate the accuracy and processivity of repair-associated DNA polymerases (Pol β, Pol δ) through incorporation assays using correct and incorrect nucleotides. This includes analyzing misincorporation rates and measuring enzyme performance on damaged DNA substrates.
DNA Repair Enzyme CharacterizationView internship →
High-Resolution Structural Analysis of Repair Complexes
Interns will participate in X-ray crystallography or cryo-electron microscopy studies of DNA repair enzyme complexes, including sample preparation, data collection, and structural refinement. They will contribute to understanding atomic-level mechanisms of DNA damage recognition and catalysis.
DNA Repair Enzyme CharacterizationView internship →
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