ADME Prediction — Absorption, Distribution, Metabolism & Excretion — Hands-on

Develop hands-on skills in in silico ADME prediction across absorption, distribution, metabolism and excretion. You will assemble small ADME panels, interpret key properties, flag liabilities early and summarize risk profiles that support medicinal chemistry decisions and preclinical planning.

ADME Prediction — Absorption, Distribution, Metabolism & Excretion

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Session Index

Session 1 — ADME Principles & Property Panels Session 2 — Absorption & Distribution Prediction Session 3 — Metabolism, Clearance & Excretion Session 4 — Mini Capstone: ADME Risk Profiling

Session 1

Fee: Rs 8800

ADME Principles & Property Panels

ADME concepts in discovery projects

absorption / distribution metabolism / excretion PK vs PD (high level)

In silico ADME property panels

logP / logD pKa and ionization solubility & permeability surrogates

Toolchain and data handling basics

RDKit descriptors spreadsheet / KNIME panels series-level summaries

Session 2

Fee: Rs 11800

Absorption & Distribution Prediction

Absorption related properties & surrogates

HIA & oral absorption flags Caco-2 / PAMPA concepts BCS-style thinking (high level)

Distribution and tissue exposure aspects

plasma protein binding surrogates volume of distribution patterns tissue partitioning indicators

Interpreting A/D panels for design feedback

linking properties to exposure flagging high-risk regions simple adjustment ideas

Session 3

Fee: Rs 14800

Metabolism, Clearance & Excretion

Metabolism concepts & soft spots

Phase I / Phase II overview likely sites of metabolism stability surrogates

Clearance, half-life & excretion pathways

hepatic vs renal emphasis simple CL and t½ indicators dose frequency implications

Interactions and high-level DDI flags (conceptual)

enzyme / transporter focus overlap in pathways ideas when to seek expert input

Session 4

Fee: Rs 18800

Mini Capstone: ADME Risk Profiling

Build an ADME panel for a small series

Theory + Practical

Interpret absorption, distribution, metabolism & clearance flags

series-level comparison identify high-risk compounds prioritize for follow up

Deliverables: ADME summary table & short risk narrative

spreadsheet with key properties traffic light style flags PDF/HTML summary note

PDF

ADME Prediction — Absorption, Distribution, Metabolism & Excretion Training | In Silico ADME Panels

ADME Prediction — Absorption, Distribution, Metabolism & Excretion — Hands-on