ADMET TOX Prediction & PK PD Interfaces — Hands-on

Develop practical skills in ADMET and toxicity prediction and understand how these outputs link to pharmacokinetics and pharmacodynamics thinking. This module covers in silico ADMET workflows, interpretation of key endpoints, simple PK PD interfaces and risk maps so that you can support discovery teams with better developability and safety aware decisions.

ADMET TOX Prediction & PK PD Interfaces

Help Desk · WhatsApp

Session Index

Session 1 — ADMET & PK PD Foundations Session 2 — In Silico ADMET & TOX Workflows Session 3 — PK PD Interfaces & Decision Support Session 4 — Mini Capstone: ADMET PK PD Profile & Risk Map

Session 1

Fee: Rs 8800

ADMET & PK PD Foundations

ADMET and PK PD in the discovery to development continuum

absorption distribution metabolism excretion toxicity concepts and safety margins PK PD language for discovery teams

Key experimental and in silico ADMET readouts

solubility and permeability metabolic stability and clearance protein binding and distribution proxies

Simple PK PD views of exposure and effect

Cmax AUC half life and clearance EC50 IC50 and potency relations exposure response and safety windows

Session 2

Fee: Rs 11800

In Silico ADMET & TOX Workflows

Data sources and curation for ADMET modeling

public and internal assay data unit harmonization and conditions binary vs continuous endpoints

Standard ADMET and TOX prediction panels

permeability solubility and clearance models hERG and cardiac liability flags hepatotoxicity and off target alerts

Model performance and domain of applicability checks

classification vs regression metrics false positive vs false negative costs distance based applicability domain

Session 3

Fee: Rs 14800

PK PD Interfaces & Decision Support

Linking ADMET predictions to simple PK views

from clearance and volume to half life oral vs intravenous exposure thoughts brain penetration and distribution flags

Using ADMET and TOX outputs in design decisions

traffic light and score based summaries combining potency and exposure early safety risk flags

Communicating ADMET PK PD risks to project teams

simple plots and tables for chemists risk maps and mitigation options flagging compounds for follow up studies

Session 4

Fee: Rs 18800

Mini Capstone: ADMET PK PD Profile & Risk Map

Building an in silico ADMET and TOX profile for a small set

Theory + Practical

Connecting predictions to simple PK PD reasoning

exposure potential vs potency flags for clearance solubility and safety prioritizing compounds for further work

Deliverables: ADMET PK PD summary and risk map

spreadsheet with key endpoints traffic light style risk visualization short narrative for project decision meeting

PDF

ADMET TOX Prediction & PK PD Interfaces Training | In Silico ADMET, TOX & PK PD Links

ADMET TOX Prediction & PK PD Interfaces — Hands-on