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Antibody Engineering & Humanization Informatics Training | Numbering, CDR Grafting, Developability & Docking

NTHRYS >> Services >> Academic Services >> Training Programs >> Bioinformatics Training >> Proteomics, Structural Bioinformatics, Molecular Modeling >> Antibody Engineering & Humanization Informatics Training | Numbering, CDR Grafting, Developability & Docking

Antibody Engineering & Humanization Informatics — Hands-on

Turn an antibody template into an experiment-ready, humanized lead with clear computational evidence. Learn sequence/structure annotation, humanization strategies, developability risk screening, interface modeling with the antigen, and how to package decisions into reproducible reports.

Antibody Engineering & Humanization Informatics
Help Desk · WhatsApp
Session 1
Fee: Rs 6300
Antibody Anatomy, Numbering & Databases
  • Heavy/light chains, frameworks, CDRs; Kabat/Chothia/IMGT schemes & paratope basics
    • Theory
  • Annotation & numbering pipelines
    • ANARCI AbNum/IMGT CDR extraction
  • Key resources & modelers
    • SAbDab/Thera-SAbDab OAS (Observed Antibody Space) ABodyBuilder/ABlooper IgFold (overview)
Session 2
Fee: Rs 8400
Humanization: CDR Grafting & Backmutations
  • Selecting human frameworks, canonical classes & CDR grafting workflow
    • sequence identity/structure fit vernier/packing residues backmutation rationale
  • Humanness scoring & immunogenicity minimization (in silico)
    • T20 score/H-score (overview) germline proximity motif constraints
  • Structure checks after grafting (geometry/contacts/clashes)
    • minimization loop sanity
Session 3
Fee: Rs 11200
Developability, Liabilities & Interface Modeling
  • Developability & biophysical risk screens (in silico)
    • aggregation/patchiness pI/viscosity risk (heuristics) glyco motifs (NXS/T)
  • Chemical liabilities & sequence filters
    • Asn deamidation Asp isomerization succinimide hotspots
  • Antigen interface modeling (overview)
    • PatchDock/HADDOCK RosettaDock contact maps/epitope sanity
Session 4
Fee: Rs 14000
Mini Capstone: Template → Humanized Candidate
  • Choose frameworks, graft CDRs, propose backmutations and justify with developability & interface evidence
    • Theory + Practical
  • Provenance & reproducibility bundle (configs, sequences, models, logs)
    • YAML/JSON configs Quarto summary variant tables
  • Deliverables: figures, tables, README & manifest
    • PDF CSV/TSV checksums


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