Antigen Processing & Presentation — MHC I & II — Hands-on

Develop a working, computation-ready understanding of how peptides are generated, processed and displayed on MHC class I and II molecules. This module connects cell biology and genetics of MHC pathways to the kinds of peptide sets, restrictions and features used in immunoinformatics, epitope prediction and reverse vaccinology pipelines.

Antigen Processing & Presentation — MHC I & II

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Session Index

Session 1 — MHC Genetics, Polymorphism & Expression Session 2 — Antigen Processing Pathways — Class I Session 3 — Antigen Processing Pathways — Class II & Cross-Presentation Session 4 — From Peptide Repertoires to Epitope Pipelines

Session 1

Fee: Rs 8800

MHC Genetics, Polymorphism & Expression

MHC loci, class I vs class II regions and nomenclature

HLA-A, -B, -C HLA-DR, -DQ, -DP alleles, supertypes, haplotypes

Polymorphism, linkage and population diversity

peptide binding groove variation frequency distributions in populations implications for vaccine coverage

MHC expression, regulation and induction by infection

constitutive vs induced expression IFN driven upregulation immune evasion by downregulation

Session 2

Fee: Rs 11800

Antigen Processing Pathways — Class I

Endogenous antigen sources and proteasomal processing

cytosolic proteins & DRiPs constitutive vs immunoproteasome peptide length distributions

TAP transport, ER trimming and peptide loading complex

TAP specificity and transport ERAP trimming tapasin and loading complex

Cell surface display and CD8 T cell recognition

stability and half life of pMHC I anchor residues and motifs link to CTL epitopes

Session 3

Fee: Rs 14800

Antigen Processing Pathways — Class II & Cross-Presentation

Exogenous antigen uptake and endosomal processing

phagocytosis & endocytosis endosomal/lysosomal proteases pH dependence & peptide pools

Invariant chain, CLIP exchange and HLA-DM/HLA-DO

biosynthesis of MHC II Ii/CLIP removal peptide editing and selection

Cross-presentation routes and CD4/CD8 coordination

vacuolar vs cytosolic routes dendritic cell specialization helper T cell support for CTL

Session 4

Fee: Rs 18800

From Peptide Repertoires to Epitope Pipelines

Conceptual link between processing pathways and epitope features

anchor motifs and pockets length preferences and flanking regions processing-aware scoring

Interpreting mass-spectrometry ligandomics / immunopeptidomes (conceptual)

eluted ligand datasets motif extraction benchmarking prediction tools

Mini exercise: sketching a processing-aware vaccine design workflow

from proteome to candidate peptides MHC coverage and filtering handoff to B/T epitope modules

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Antigen Processing & Presentation MHC I & II Training | Pathways, Peptides, Epitope Context

Antigen Processing & Presentation — MHC I & II — Hands-on