Autoimmunity Risk & Cross-Reactivity Analysis — Hands-on

Develop a safety-aware view of autoimmunity risk and cross-reactivity in the context of vaccines, antibodies and T cell–based approaches. This module focuses on conceptual frameworks for self/non-self discrimination, molecular mimicry, tissue risk and how to read epitope and neoantigen results with an autoimmunity lens for translational projects.

Autoimmunity Risk & Cross-Reactivity Analysis

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Session Index

Session 1 — Autoimmunity & Immune Tolerance Foundations Session 2 — Cross-Reactivity & Molecular Mimicry Concepts Session 3 — Risk Framing for Vaccines & Biologics Session 4 — Case Sketches & Risk Communication

Session 1

Fee: Rs 8800

Autoimmunity & Immune Tolerance Foundations

Self/non-self and danger concepts in simple language

how immune systems normally avoid attacking self role of context, inflammation and danger signals where this picture can break down in autoimmunity

Tolerance checkpoints overview (conceptual, no equations)

central tolerance ideas for T and B lymphocytes peripheral tolerance, regulation and exhaustion notions how tolerance relates to epitope and neoantigen thinking

Autoimmune diseases as examples (high level only)

organ specific and systemic conditions in concept tissue targets and clinical manifestations overview motivation for careful risk thinking in vaccine design

Session 2

Fee: Rs 11800

Cross-Reactivity & Molecular Mimicry Concepts

What cross-reactivity means for B and T cells (conceptual)

one receptor recognising multiple related patterns binding strength versus functional response ideas why cross-reactivity can be both helpful and risky

Molecular mimicry between pathogen and host structures (in plain language)

sequence and shape level similarity concepts examples of shared motifs at a high level (no case details) links to epitope mapping and structural modules in this category

Where mimicry and cross-reactivity show up in analysis outputs

epitope lists with potential self-like segments neoantigen candidates near conserved self regions antibody and TCR motifs with host similarity signals

Session 3

Fee: Rs 14800

Risk Framing for Vaccines & Biologics

Dimensions that influence autoimmunity risk (conceptual matrix)

degree of similarity to self and critical tissues tissue expression, accessibility and immune privilege ideas host genetics, HLA context and history in simple terms

Risk thinking for different modality types (high level)

protein and peptide vaccines in concept mRNA/viral vector vaccines and expression location ideas antibodies and cell-based approaches at an overview level

Integrating risk flags into epitope and neoantigen shortlists

soft exclusion and caution categories in principle balancing potency, breadth and safety narratives handshake with clinical, safety and regulatory viewpoints

Session 4

Fee: Rs 18800

Case Sketches & Risk Communication

Sketching hypothetical scenarios with different risk profiles

low, medium and elevated risk storylines (conceptual) how flags might change design or monitoring ideas link back to formulation, adjuvant and regimen choices

Communicating autoimmunity risk to non specialists (plain language)

clear statements of what is known versus uncertain simple visuals and tables for risk categories aligning messages across R&D, clinical and communication teams

Documenting assumptions, mitigations and follow-up plans

brief risk commentary sections in reports capturing monitoring and escalation triggers conceptually handoff to safety, pharmacovigilance and regulatory tracks

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Autoimmunity Risk & Cross-Reactivity Analysis Training | Safety-Aware Immunoinformatics Concepts

Autoimmunity Risk & Cross-Reactivity Analysis — Hands-on