Biomarker Discovery — Panels & Clinical Validation Training | Study Design to Performance Metrics

Learn how to move from metabolite candidates to clinically useful biomarker panels, covering study design, panel building, performance metrics and validation workflows for translational readiness.

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Biomarker Discovery — Panels & Clinical Validation — Hands-on

Bridge discovery and translation by designing realistic biomarker studies and panel workflows. This module focuses on how to select and evaluate metabolite (and multi-omics) candidates, build biomarker panels, interpret diagnostic performance metrics, and plan technical/clinical validation so that your results are ready for real-world decision support.

Biomarker Discovery — Panels & Clinical Validation

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Session Index

Session 1 — Biomarker Study Design & Clinical Context Session 2 — Candidate Discovery, Panels & Performance Metrics Session 3 — Technical Validation & Clinical Readiness Concepts Session 4 — Mini Capstone: Biomarker Panel Report & Checklist

Session 1

Fee: Rs 8800

Biomarker Study Design & Clinical Context

What makes a good biomarker and biomarker panel (concepts)

prognostic vs diagnostic vs predictive clinical question and use case clarity single markers vs panels

Cohort and study design for biomarker discovery

case–control vs longitudinal ideas sample size and enrichment thinking confounders and stratification

Discovery vs validation phases and data partitioning

training / validation / test splits internal vs external validation concepts avoiding information leakage

Session 2

Fee: Rs 11800

Candidate Discovery, Panels & Performance Metrics

From differential metabolites to candidate biomarkers

effect sizes and stability biological plausibility concepts shortlisting candidates systematically

Building panels and simple multivariable models (concept level)

combining markers for improved performance overfitting awareness and parsimony cross-validation ideas

Diagnostic performance metrics and interpretation

sensitivity, specificity, accuracy ROC curves and AUC concepts PPV, NPV and prevalence impact

Session 3

Fee: Rs 14800

Technical Validation & Clinical Readiness Concepts

Technical validation and assay performance (concepts)

precision and repeatability LLOQ, ULOQ, linearity ideas matrix effects awareness

Cut-offs, risk scores and clinical decision thresholds

Youden index style cut-point ideas risk stratification into groups trade-offs between sensitivity and specificity

Independent validation cohorts and generalisability (high level)

multi-center and multi-ethnic ideas sample handling consistency reporting limitations transparently

Session 4

Fee: Rs 18800

Mini Capstone: Biomarker Panel Report & Checklist

Summarising a toy biomarker panel from discovery to validation

Theory + Practical

Preparing a concise biomarker panel summary for stakeholders

marker list and panel description key performance metrics table intended use and next steps

Deliverables: biomarker panel sheet, metrics table & validation checklist

panel summary (PDF/HTML) performance metrics table (CSV/TSV) clinical validation readiness checklist