Biotransformation Pathways & Metabolite Prediction — Hands-on

Build a working understanding of biotransformation pathways and metabolite prediction in drug discovery. You will review Phase I/II reactions, enzyme systems, soft spots and reactive metabolite risks, then apply simple in silico tools and cheminformatics workflows to map likely pathways, summarize metabolic liabilities and support medicinal chemistry decisions.

Biotransformation Pathways & Metabolite Prediction

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Session Index

Session 1 — Biotransformation Concepts & Enzyme Systems Session 2 — Metabolic Pathways & Metabolite Prediction Session 3 — Reactive Metabolites, Soft Spots & Tuning Session 4 — Mini Capstone: Series Biotransformation Map

Session 1

Fee: Rs 8800

Biotransformation Concepts & Enzyme Systems

Biotransformation in drug discovery & development

ADME and clearance linkage safety and efficacy impact exposure and metabolite balance

Phase I & Phase II reactions (high level view)

oxidation, reduction, hydrolysis conjugation (UGT, SULT, GST) qualitative patterns, not equations

Enzyme systems and tissue context (concepts)

CYP families overview extrahepatic metabolism ideas species and tissue differences (high level)

Session 2

Fee: Rs 11800

Metabolic Pathways & Metabolite Prediction

Common metabolic transformations & pathways

aromatic & aliphatic oxidations dealkylation and deamination hydrolysis and conjugates

In silico metabolite prediction (practical view)

likely sites of metabolism proposed metabolite structures ranking and plausibility checks

Visualizing and annotating metabolic pathways

reaction-style schemes parent–metabolite trees series-level comparison views

Session 3

Fee: Rs 14800

Reactive Metabolites, Soft Spots & Tuning

Soft spots and metabolic stability concepts

liability-bearing motifs rapid clearance patterns balancing clearance and exposure

Reactive metabolites & safety considerations (high level)

bioactivation motifs (conceptual) covalent binding ideas structural risk flags

Qualitative tuning strategies for metabolism

blocking soft spots shifting metabolic routes series-level design suggestions

Session 4

Fee: Rs 18800

Mini Capstone: Series Biotransformation Map

Predict likely metabolites for a small series

Theory + Practical

Assemble a qualitative biotransformation map

parent–metabolite schemes soft spot & liability flags series comparison snapshot

Deliverables: pathway figure & short metabolism note

image or slide of pathways table of key metabolites PDF/HTML narrative summary

PDF

Biotransformation Pathways & Metabolite Prediction Training | Drug Metabolism & Metabolite Risk

Biotransformation Pathways & Metabolite Prediction — Hands-on