Capstone — Structure-to-Function & Design Project — Hands-on

Bring together everything you have learned in structural bioinformatics, protein engineering and biophysics into a single, narrative-driven project. In this capstone you will scope a real-world problem, assemble structural data, design a modelling and analysis plan, and produce a portfolio-grade report and presentation.

Capstone — Structure-to-Function & Design Project

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Session Index

Session 1 — Problem Scoping & Data Inventory Session 2 — Modelling & Analysis Workflow Blueprint Session 3 — Results, Validation & Visual Story Session 4 — Final Report, Presentation & Portfolio

Session 1

Fee: Rs 30800

Problem Scoping & Data Inventory

Selecting a capstone theme and biological question

enzyme mechanism or stability problem antibody/ligand binding question membrane or multi-domain system idea

Data discovery and inventory (structures & sequences)

PDB / AlphaFold / homology models (concept) cryo-EM/X-ray/NMR maps (if applicable) mutations, PTMs and ligands of interest

Defining scope, success criteria and outputs

what decisions the project should support time-boxing and complexity control checklist of expected deliverables

Session 2

Fee: Rs 34800

Modelling & Analysis Workflow Blueprint

Choosing appropriate structural workflows

remediation / validation and model building docking and interface analysis (concept) conformational landscape or MD reasoning

Planning variant, PTM or design scenarios

which mutations or designs to explore what hypotheses each scenario will test expected structural/biophysical readouts

Workflow mapping and documentation concepts

simple flow diagrams for analysis steps inputs, intermediate artifacts and outputs notes on assumptions and limitations

Session 3

Fee: Rs 38800

Results, Validation & Visual Story

Consolidating structural and biophysical findings

before/after or state A/state B comparisons interfaces, hotspots and stability summaries aligning results back to the original question

Validation checks and sanity filters (conceptual)

basic structure and geometry checks consistency across methods and states flagging over-interpretation risks

Designing a clear visual narrative

core figure set (cartoons, surfaces, plots) colour and annotation choices for clarity ordering figures to tell a logical story

Session 4

Fee: Rs 41800

Final Report, Presentation & Portfolio

Structuring the capstone report

background, objective and methods summaries results, discussion and limitations design or experimental follow-up proposals

Slide deck and oral presentation pointers

5–10 slide story arc speaking to mixed technical audiences highlighting decisions and impact, not just methods

Deliverables: portfolio-ready capstone package

report (PDF/HTML) and slide deck figure bundle and structural sessions summary one-page project brief for CV/LinkedIn

PDF

Capstone Structure-to-Function & Design Project Training | Integrated Structural Bioinformatics Project

Capstone — Structure-to-Function & Design Project — Hands-on