Clinical Glycomics — Biomarkers and Disease Signatures — Hands-on

Translate glycomics into clinically meaningful biomarkers and disease signatures. This module covers study design for clinical glycomics, sample handling and pre analytics, LC–MS based glycan profiling workflows, and statistical modeling of glycan features for diagnostics, prognosis and treatment response signatures.

Clinical Glycomics — Biomarkers and Disease Signatures

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Session Index

Session 1 — Clinical Glycomics Foundations Session 2 — Study Design, Samples & Pre-analytics Session 3 — Data Analysis, Biomarker Panels & Validation Session 4 — Mini Capstone: Glycan Disease Signature Build

Session 1

Fee: Rs 8800

Clinical Glycomics Foundations

Role of glycans in disease and clinical phenotypes

inflammation and immune modulation cancer, infection and metabolic disease ageing and chronic disorders

What is clinical glycomics and where it is used

diagnostic and prognostic biomarkers treatment response and stratification companion diagnostics and trials

Overview of clinical sample types for glycomics

serum, plasma and whole blood CSF, urine and saliva tissue extracts and FFPE sections

Session 2

Fee: Rs 11800

Study Design, Samples & Pre-analytics

Cohort design for glycan biomarker studies

case control and longitudinal designs inclusion and exclusion criteria confounders and covariates

Pre analytical variables and stability of glycans

collection tubes and clotting time processing delays and storage freeze thaw and batch effects

Clinical and regulatory considerations at design stage

informed consent and ethics data privacy and coding sample tracking and metadata capture

Session 3

Fee: Rs 14800

Data Analysis, Biomarker Panels & Validation

From LC–MS glycan data to feature tables

peak picking and integration alignment and batch correction deriving glycan traits and summary indices

Statistical analysis for glycan biomarker discovery

univariate testing and multiple testing control multivariate models and feature selection ROC curves and AUC metrics

Building and evaluating glycan biomarker panels

sensitivity, specificity and cutoffs cross validation and holdout sets independent validation and reporting

Session 4

Fee: Rs 18800

Mini Capstone: Glycan Disease Signature Build

Working with a small clinical glycan dataset

Theory plus Practical

Deriving a candidate glycan biomarker panel

feature filtering and selection strategy simple classification model build performance metrics and caveats

Deliverables: biomarker table, performance plots and clinical summary

CSV or XLSX feature and trait table ROC and calibration style plots short PDF or PPTX interpretation for clinicians

PDF

Clinical Glycomics Biomarkers & Disease Signatures Training | Study Design to ROC Curves

Clinical Glycomics — Biomarkers and Disease Signatures — Hands-on