Clinical Microbiome & Diagnostic Biomarkers — Hands-on

Learn how to move from microbiome sequencing tables to clinically interpretable biomarkers. This module covers study design for clinical microbiome projects, pipelines and quality checks, feature selection and modelling, diagnostic performance metrics, and reporting for clinicians, regulators, and translational research partners.

Clinical Microbiome & Diagnostic Biomarkers

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Session Index

Session 1 — Clinical Microbiome Use Cases & Study Design Session 2 — Pipelines, QA/QC & Feature Spaces Session 3 — Biomarker Modelling, Validation & Interpretation Session 4 — Mini Capstone: Clinical Microbiome Biomarker Report

Session 1

Fee: Rs 8800

Clinical Microbiome Use Cases & Study Design

Clinical and translational microbiome scenarios

gut, oral, skin and respiratory microbiomes infection risk and dysbiosis signatures oncology, metabolic and immune applications

Study designs for microbiome biomarkers

case control, cohort and nested case control prospective vs retrospective collections endpoints and clinical inclusion criteria

Pre analytical variables and metadata essentials

sampling site, kit and storage details medications, antibiotics and diet covariates simple bias and confounding awareness

Session 2

Fee: Rs 11800

Pipelines, QA/QC & Feature Spaces

Clinical grade microbiome pipelines (concept level)

amplicon vs shotgun for diagnostics contamination checks and controls overview batch effects and run level QC thinking

Feature spaces for biomarker discovery

taxa at ASV, species and genus levels pathways, gene families and modules diversity scores and composite indices

Cleaning, normalisation and train test splits

zero handling and transformations feature filtering and prevalence thresholds avoiding information leakage across splits

Session 3

Fee: Rs 14800

Biomarker Modelling, Validation & Interpretation

Feature selection and modelling strategies

univariate screening ideas regularised models and tree based methods overview simple risk scores and composite indices

Diagnostic performance and validation concepts

sensitivity, specificity and accuracy ROC, PR curves and AUC metrics internal vs external validation thinking

Clinical interpretation and reporting

class level summaries instead of raw features confidence intervals and uncertainty awareness do and do not examples for reports and slides

Session 4

Fee: Rs 18800

Mini Capstone: Clinical Microbiome Biomarker Report

Designing a compact biomarker analysis workflow

guided theory plus practical

From feature table to diagnostic panel summary

select a small feature set or index build ROC style plots and calibration views compare against simple baselines and covariates

Deliverables: figures, tables and short clinical narrative

ROC and performance summary plots feature importance or coefficient tables brief report written for clinicians or translational teams

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Clinical Microbiome & Diagnostic Biomarkers Training | Microbiome-Based Diagnostics & Risk Scores

Clinical Microbiome & Diagnostic Biomarkers — Hands-on