Drug–Gene and Drug–Drug–Gene Interactions — Hands-on

Learn how pharmacogenomic phenotypes modify classic drug drug interactions and how to recognise high risk drug gene and drug drug gene combinations in practice. This module links metabolic and transporter phenotypes with inhibitors, inducers and polypharmacy patterns to support safer, interaction aware prescribing.

Drug–Gene and Drug–Drug–Gene Interactions

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Session Index

Session 1 — Fundamentals of Drug–Gene Interactions Session 2 — Drug–Drug and Drug–Drug–Gene Interactions Session 3 — Clinical Scenarios & Risk Stratification Session 4 — Mini Capstone: Interaction Aware PGx Summary

Session 1

Fee: Rs 8800

Fundamentals of Drug–Gene Interactions

What is a drug–gene interaction in PGx context

gene driven PK variation PD targets and receptors efficacy and toxicity outcomes

Role of metabolic and transporter phenotypes

CYP poor vs ultra rapid metabolizers SLCO and ABC transporters baseline exposure differences

Concept of gene based dose thresholds and windows

narrow therapeutic index drugs up titration and monitoring when PGx is critical

Session 2

Fee: Rs 11800

Drug–Drug and Drug–Drug–Gene Interactions

Classic PK based drug–drug interactions (DDI)

inhibition and induction competitive and mechanism based time course of effect

What changes in a drug–drug–gene interaction (DDGI)

phenotype plus inhibitor scenario phenoconversion concept overlap of multiple pathways

Simple mental models for DDGI risk levels

high risk phenotypes with strong inhibitors compensation by parallel pathways when to consider alternatives

Session 3

Fee: Rs 14800

Clinical Scenarios & Risk Stratification

Polypharmacy examples with PGx phenotypes

antidepressants and pain medicines antiplatelets and PPIs statins with interacting drugs

Risk stratification for exposure and toxicity

low vs moderate vs high risk combinations patient factors and comorbidities role of TDM where available

Interaction checking tools with PGx awareness (concept)

standard DDI checkers adding phenotype overlays flagging and documentation

Session 4

Fee: Rs 18800

Mini Capstone: Interaction Aware PGx Summary

Worked case with gene, perpetrator and victim drugs

identify PGx phenotype map inhibitors and inducers estimate relative exposure change

Drug–Gene and Drug–Drug–Gene Interactions Training | PGx Phenotypes, DDIs & Clinical Risk

Drug–Gene and Drug–Drug–Gene Interactions — Hands-on