Hit to Lead Optimization & Multi Parameter Design — Hands-on

Learn how discovery teams move from preliminary hits to more reliable lead series using data driven, multi parameter thinking. This module focuses on hit series triage, SAR interpretation, property and liability profiling, and multi parameter design approaches so that you can propose and defend sensible next round designs for medicinal chemistry programs.

Hit to Lead Optimization & Multi Parameter Design

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Session Index

Session 1 — Hit to Lead Foundations & Series Triage Session 2 — Multi Parameter Optimization & Property Space Session 3 — Design Strategies, SAR & Decision Making Session 4 — Mini Capstone: Hit to Lead Plan & Scorecard

Session 1

Fee: Rs 8800

Hit to Lead Foundations & Series Triage

From screening hits to lead candidates

definitions of hit, lead and backup screening cascade concepts working with noisy early data

Hit series triage and prioritization

evaluating tractability and novelty simple property and liability checks risk benefit framing for series

Core data package for hit to lead decisions

potency and selectivity profile basic ADMET and exposure readouts early chemistry feasibility view

Session 2

Fee: Rs 11800

Multi Parameter Optimization & Property Space

Thinking in property and liability space

key physchem drivers for leads simple exposure and clearance heuristics safety and off target flags

Multi parameter optimization basics

balancing potency, selectivity and exposure property windows and soft limits radar plots and traffic light schemes

Simple multi parameter scores and ranking tables

normalization and weighting of terms scorecards vs raw metric tables communicating trade offs to teams

Session 3

Fee: Rs 14800

Design Strategies, SAR & Decision Making

Reading and visualizing SAR in hit to lead

matched molecular pairs views simple 2D SAR maps spotting cliffs and flat regions

Design moves for potency and property tuning

scaffold, linker and side chain changes heteroatom and ring edits property driven substitution patterns

Decision making and next round proposals

narrowing to a small design set linking designs to hypotheses simple go, grow or stop calls

Session 4

Fee: Rs 18800

Mini Capstone: Hit to Lead Plan & Scorecard

Building a simple hit to lead scorecard

Theory + Practical

Applying multi parameter ranking to a small series

populate metrics and scores identify preferred chemotypes flag key risks and options

Deliverables: prioritized series and next round proposals

scorecard and ranking table short slide deck for team review annotated list of design ideas

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Hit to Lead Optimization & Multi Parameter Design Training | SAR, Property Space & MPO

Hit to Lead Optimization & Multi Parameter Design — Hands-on