HLA Typing & Immunogenetics Informatics — Hands-on

Build validated HLA typing pipelines for clinical and translational applications. This hands-on module covers IPD-IMGT/HLA resources, NGS data processing for Class I/II loci, phasing and ambiguity resolution, G and P group handling, KIR typing overview, quality metrics, and transplant/research reporting with audit-ready documentation.

HLA Typing & Immunogenetics Informatics

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Session Index Category 5 · Clinical & Translational Bioinformatics

Session 1 — Foundations: HLA System & Databases Session 2 — NGS Typing Pipelines & Phasing Session 3 — Ambiguities, G/P Groups & KIR Overview Session 4 — Validation, Reporting & EHR Integration

Session 1

Fee: Rs 17720

Foundations: HLA System & Databases

HLA & immunogenetics essentials

Class I (A, B, C) Class II (DRB1/3/4/5, DQA1/DQB1, DPA1/DPB1) peptide presentation overview

Nomenclature & references

IPD-IMGT/HLA allele fields (2/3/4-digit) G/P groups

Assays & study design

amplicon vs capture read length/coverage long-read notes

Session 2

Fee: Rs 21920

NGS Typing Pipelines & Phasing

Tools & workflows (short/long reads)

OptiType / Polysolver / xHLA arcasHLA / HISAT-genotype minimap2 + HLA*LA (overview)

Phasing & ambiguity sources

exon/intron coverage read length & mapping database version drift

QC & performance metrics

depth/uniformity/allele balance call confidence & flags replicates/controls

Session 3

Fee: Rs 26120

Ambiguities, G/P Groups & KIR Overview

Ambiguity resolution strategies

phase-aware refinement consensus across tools orthogonal assays (high-level)

Groups, supertypes & epitopes (Bw4/6)

G/P groups C1/C2 epitopes DPB1 TCE (overview)

KIR typing & compatibility (overview)

KIR genes/ligands AA/Bx content NK education context

Session 4

Fee: Rs 31720

Validation, Reporting & EHR Integration

Analytical validation & QC

accuracy/precision reportable range proficiency testing

Transplant/matching & reports

typing resolution & match grades antibody/epitope context limitations & SOPs

EHR/FHIR integration & governance

FHIR Genomics profiles CDS hooks (high-level) audit trails & versioning

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HLA Typing & Immunogenetics Informatics | NGS Typing, Phasing & Clinical Reporting

HLA Typing & Immunogenetics Informatics — Hands-on