Immunogenicity & Allergenicity Prediction — Hands-on

Understand how and why vaccine constructs and biologics may trigger unwanted immune responses. This module focuses on conceptual frameworks and in silico readouts for immunogenicity and allergenicity, helping you interpret epitope burden, self similarity, allergen like features and cross reactivity risk for translational and regulatory facing teams.

Immunogenicity & Allergenicity Prediction

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Session Index

Session 1 — Immunogenicity Concepts & Risk Landscape Session 2 — In Silico Immunogenicity Readouts Session 3 — Allergenicity Frameworks & Prediction Session 4 — Integrated Safety Story & Reporting

Session 1

Fee: Rs 8800

Immunogenicity Concepts & Risk Landscape

Clinical and translational view of immunogenicity risk

vaccines versus therapeutic biologics anti drug antibodies and impact on efficacy hypersensitivity and safety concerns

Molecular and host level drivers of immunogenicity (conceptual)

sequence novelty and non self patterns aggregation, impurities and PTMs host genetics and immune status

Role of in silico prediction in broader risk assessment

supporting but not replacing experiments qualitative risk flags and ranking positioning outputs for decision makers

Session 2

Fee: Rs 11800

In Silico Immunogenicity Readouts

T cell epitope burden and HLA coverage as risk indicators

density of MHC class I and II binders distribution across construct regions link to target populations conceptually

Self similarity and homology based considerations (conceptual)

sequence similarity to host proteome shared epitope like motifs balancing efficacy and tolerance ideas

Qualitative rating of immunogenic hot spots (conceptual)

clustered high affinity binders regions near novel junctions or linkers mapping to construct and sequence diagrams

Session 3

Fee: Rs 14800

Allergenicity Frameworks & Prediction

Overview of allergen families and IgE mediated responses

common structural and sequence themes cross reactive allergen families (conceptual) clinical manifestation overview

Sequence pattern and property based allergenicity cues (conceptual)

motif and epitope like patterns physicochemical and structural hints link to known allergen reference sets

Cross reactivity risk orientation for constructs and components

sequence similarity to known allergens excipient, tag and fusion partner considerations flagging regions for further evaluation

Session 4

Fee: Rs 18800

Integrated Safety Story & Reporting

Combining immunogenicity and allergenicity flags into a single view

region wise risk summary tables colour coded heatmap style overviews clear distinction between data and judgement

Drafting a concise qualitative risk narrative (conceptual)

assumptions and limitations statement high, moderate and low concern language recommended experimental follow ups

Handoff to regulatory, clinical and formulation stakeholders (conceptual)

content suitable for slide decks and reports aligning with organisational risk frameworks link to regulatory pathways module in this category

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Immunogenicity & Allergenicity Prediction Training | Safety Oriented In Silico Assessment

Immunogenicity & Allergenicity Prediction — Hands-on