Network Based Drug Repurposing & Target Prioritization — Hands-on

Learn how to use biological and pharmacological networks to systematically identify repurposing opportunities and prioritise targets. This module walks through building drug–target–disease graphs, applying network propagation and scoring strategies, and integrating omics and clinical evidence into decision grade shortlists.

Network Based Drug Repurposing & Target Prioritization

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Session Index

Session 1 — Network Based Drug Discovery & Repurposing Foundations Session 2 — Building Drug–Target–Disease Networks Session 3 — Network Propagation, Scoring & Prioritization Session 4 — Mini Capstone: Repurposing & Target Shortlist

Session 1

Fee: Rs 8800

Network Based Drug Discovery & Repurposing Foundations

Why network views for drug discovery and repurposing

polypharmacology and network neighbourhoods disease modules vs single targets opportunities for repurposing at scale

Key network medicine concepts for drug design

proximity of drugs to disease modules off target and safety neighbourhoods network controllability intuition

Data landscape for network based repurposing

drug target and indication resources omics and disease gene sources clinical and real world evidence pointers

Session 2

Fee: Rs 11800

Building Drug–Target–Disease Networks

Drug, target and disease data integration

ChEMBL, DrugBank, DGIdb style sources disease gene sets and interactomes ID mapping and harmonisation

Graph construction and projections for analysis

bipartite drug–target graphs projected drug–drug and target–target networks drug proximity to disease modules

Toolchains for drug–target–disease networks

NetworkX / igraph scripting Cytoscape for interactive layouts reproducible data and graph formats

Session 3

Fee: Rs 14800

Network Propagation, Scoring & Prioritization

Proximity and diffusion based scoring of candidates

shortest path and distance metrics random walk and diffusion ideas null models and significance checks

Combining network scores with omics and annotations

disease specific omics overlays safety, selectivity and tractability flags multi criteria ranking approaches

Network based combination and polypharmacology ideas

covering disease modules with sets of drugs avoiding risky overlapping neighbourhoods prioritising combinations for follow up

Session 4

Fee: Rs 18800

Mini Capstone: Repurposing & Target Shortlist

Select a disease module and build a drug–target–disease graph

Theory + Practical

Run network based scoring and refine a shortlist of candidates

compute proximity / diffusion scores overlay omics and annotation filters propose repurposing and target ideas

Deliverables: networks, ranking tables and decision note

Cytoscape session or graph files CSV of scores and ranks brief rationale and next step plan

PDF

Network Based Drug Repurposing & Target Prioritization Training | Network Pharmacology & Repurposing Analytics

Network Based Drug Repurposing & Target Prioritization — Hands-on