PBPK / PD Modeling Basics & Exposure Assessment — Hands-on

Develop an intuitive, non-clinical understanding of PBPK and PK/PD modeling to support discovery and safety assessments. You will explore model structure, physiological and compound-related parameters, exposure metrics and simple scenario-based simulations to interpret how changes in properties or regimens may affect exposure, without performing clinical dose selection.

PBPK / PD Modeling Basics & Exposure Assessment

Help Desk · WhatsApp

Session Index

Session 1 — PK / PD & PBPK Conceptual Foundations Session 2 — PBPK Structure, Parameters & Scaling Ideas Session 3 — Exposure Metrics, Profiles & PD Readouts Session 4 — Mini Capstone: Simple Exposure Assessment

Session 1

Fee: Rs 8800

PK / PD & PBPK Conceptual Foundations

PK / PD basics for discovery and safety projects

concentration–time thinking exposure vs response concepts non-clinical use cases only

Compartmental vs PBPK model ideas (high level)

simple compartment analogies physiological structure concept when PBPK is useful

Key quantities and curves (qualitative view only)

Cmax / Tmax ideas AUC and exposure notions half life and persistence

Session 2

Fee: Rs 11800

PBPK Structure, Parameters & Scaling Ideas

Typical PBPK structure (conceptual, diagram based)

organ and tissue compartments blood flows & volumes (idea level) elimination organs focus

Physiological and compound-related inputs (non-clinical)

tissue volumes & flows (tables / defaults) partition coefficient concepts clearance and binding ideas

Scaling & scenario thinking (high level, non clinical)

species differences conceptually body size and physiology shifts what-if comparisons only

Session 3

Fee: Rs 14800

Exposure Metrics, Profiles & PD Readouts

Exposure metrics from simulated profiles (conceptual)

reading concentration–time curves interpreting AUC and peaks time-above-threshold ideas

Basic PD response curve concepts (no clinical guidance)

Emax / EC50 ideas exposure–response shapes qualitative potency vs exposure

Scenario comparisons and communication of results

visual overlays of profiles tables of key metrics clear non-clinical caveats

Session 4

Fee: Rs 18800

Mini Capstone: Simple Exposure Assessment

Explore a simple PBPK-style scenario (non-clinical)

Theory + Practical (conceptual)

Compare exposure profiles under different what-if conditions

changes in clearance / binding (concept) impact on AUC and peaks (qualitative) non-clinical interpretation only

Deliverables: exposure summary plots & non-clinical narrative

basic profile figures table of exposure metrics short PDF/HTML explanation note

PDF

PBPK / PD Modeling Basics & Exposure Assessment Training | Conceptual PK Modeling & Exposure Analysis

PBPK / PD Modeling Basics & Exposure Assessment — Hands-on