Physiologically Based PK — PBPK Modeling — Hands-on

Understand the principles and workflow of physiologically based pharmacokinetic (PBPK) modeling for drug development and precision dosing. This module focuses on conceptual model structure, physiological and drug related inputs, simulation scenarios for drug–drug interactions and special populations, and how to communicate PBPK based insights in reports.

Physiologically Based PK — PBPK Modeling

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Session Index

Session 1 — PBPK Foundations & Model Structure Session 2 — Parameters, Inputs & Simulation Setups Session 3 — Evaluation, DDI & Special Populations Session 4 — Mini Capstone: PBPK Case & Summary Note

Session 1

Fee: Rs 8800

PBPK Foundations & Model Structure

Why PBPK? Uses across R&D and clinical practice (conceptual)

linking physiology with PK scenario and what if analysis regulatory and label support themes

Anatomy of a PBPK model — compartments & flows (conceptual)

organ and tissue compartments blood flows and partitioning ideas perfusion vs permeability limited thinking

Workflow overview: build → calibrate → simulate → communicate

fit for purpose model planning data sources and assumptions documentation and traceability themes

Session 2

Fee: Rs 11800

Parameters, Inputs & Simulation Setups

Physiological parameter concepts and typical sources

organ volumes and blood flows age and body size relationships population variability themes

Drug related inputs for PBPK models (conceptual level)

permeability and solubility ideas plasma protein binding concepts clearance and metabolism inputs

Designing simulation scenarios and dosing regimens

single vs multiple dose patterns steady state profiles and accumulation visualizing concentration–time outputs

Session 3

Fee: Rs 14800

Evaluation, DDI & Special Populations

Comparing PBPK simulations with observed data (conceptual)

visual checks and goodness of fit ideas Cmax, AUC and half life patterns sensitivity to key parameters

Drug–drug interaction exploration with PBPK (high level)

inhibitor and inducer scenarios perpetrator vs victim drug view exposure change and dose ideas

Special populations: renal, hepatic and paediatric themes

changes in physiology and clearance line of sight to dose adjustment uncertainty and safety margins

Session 4

Fee: Rs 18800

Mini Capstone: PBPK Case & Summary Note

Select a simple PBPK scenario and outline the model

define purpose and questions list required physiological inputs capture key drug properties

Summarise simulation outcomes for clinicians and teams

time–concentration chart narratives dose and schedule implications cautions and residual uncertainty

Deliverables: PBPK case slide deck and one page summary

PDF or PPTX ready for MIDD discussions template for future PBPK projects

PDF

Physiologically Based PK — PBPK Modeling Training | Concepts, Scenarios & Exposure Prediction

Physiologically Based PK — PBPK Modeling — Hands-on