Population Genomics, Ancestry & Risk Scores (PRS) — Hands-on

Gain a practical, high level understanding of population genomics, ancestry analysis and polygenic risk scores (PRS) . This module connects cohorts, biobanks, ancestry structure and risk score concepts so that participants can read, interpret and design basic population genomics and PRS workflows for translational and clinical contexts. Content is for training and awareness, not clinical or regulatory advice.

Population Genomics, Ancestry & Risk Scores (PRS)

Help Desk · WhatsApp

Session Index

Session 1 — Population Genomics & Cohort Foundations Session 2 — Ancestry, Population Structure & Stratification Session 3 — Polygenic Risk Scores (PRS) & Risk Modeling Session 4 — Mini Capstone: Ancestry Aware PRS Snapshot

Session 1

Fee: Rs 8800

Population Genomics & Cohort Foundations

What population genomics aims to answer

allele frequencies and diversity disease risk and modifiers overview biobanks and large cohorts snapshot

Cohort designs and basic data structures (high level)

case control and cohort ideas longitudinal follow up mindset phenotypes, genotypes and covariates

Quality control thinking for population data

sample and variant level filters idea call rate, relatedness and heterozygosity snapshot batch and platform awareness mindset

Session 2

Fee: Rs 11800

Ancestry, Population Structure & Stratification

Concepts of ancestry and population structure

reference panels and background structure idea principal component style views admixture and substructure snapshot

Ancestry inference mindset for practical work

using PCs or clusters as covariates avoidable pitfalls in mixed cohorts visual summaries for QC

Population stratification and confounding (high level)

why stratification matters for association basic adjustment strategies snapshot limitations and residual confounding mindset

Session 3

Fee: Rs 14800

Polygenic Risk Scores (PRS) & Risk Modeling

What PRS tries to capture in simple terms

many variants with small effects idea relative risk and stratification snapshot concept of score distributions

High level PRS construction concepts

effect sizes and variant selection idea link to GWAS summary statistics mindset cohort specific calibration snapshot

Evaluating scores and communicating limitations

AUC and variance explained ideas ancestry transferability challenges clinical use cases and caveats overview

Session 4

Fee: Rs 18800

Mini Capstone: Ancestry Aware PRS Snapshot

Start from a toy cohort with genotypes and simple traits

Theory + Practical

Sketch an ancestry and PRS summary view

simple ancestry plot or grouping idea score distribution by ancestry snapshot basic risk bins concept

Prepare a short interpretation and caveats paragraph

what the scores might indicate ancestry and data limitations future improvements and validation ideas

PDF

Population Genomics, Ancestry & Risk Scores (PRS) Training | Cohorts, Ancestry & Polygenic Risk

Population Genomics, Ancestry & Risk Scores (PRS) — Hands-on