Population PK/PD — Nonlinear Mixed Effects Modeling — Hands-on

Build a strong conceptual foundation in population pharmacokinetics and pharmacodynamics (PopPK–PD) using nonlinear mixed-effects (NLME) thinking. You will learn how to frame PopPK–PD questions, interpret model parameters and variability, explore covariate effects and simulate dosing scenarios to support model informed drug development and precision therapy.

Population PK/PD — Nonlinear Mixed Effects Modeling

Help Desk · WhatsApp

Session Index

Session 1 — PopPK/PD Concepts & Study Designs Session 2 — NLME Parameters, Variability & Error Session 3 — Covariates, Diagnostics & Simulations Session 4 — Mini Capstone: PopPK–PD Case & Dosing

Session 1

Fee: Rs 8800

PopPK/PD Concepts & Study Designs

Why population PK/PD? Questions PopPK models can address

between patient variability exposure response themes dosing in special populations

PopPK/PD vs classical PK — conceptual differences

individual vs population focus fixed vs random effects thinking handling sparse sampling

Study designs for PopPK/PD data collection (conceptual)

intensive vs sparse designs rich and opportunistic sampling linking design to model goals

Session 2

Fee: Rs 11800

NLME Parameters, Variability & Error

Structural model concepts (one/two compartment, PD effect)

absorption and distribution ideas clearance and volume thinking direct and indirect PD responses

Random effects and variability components (conceptual)

between subject variability residual unexplained variability inter occasion variability themes

Error models and data characteristics

additive vs proportional error ideas log transformed data intuition linking error choice to data range

Session 3

Fee: Rs 14800

Covariates, Diagnostics & Simulations

Concepts for covariate screening and selection

continuous vs categorical covariates clinical plausibility first parsimony and overfitting concerns

Diagnostic plot themes for PopPK–PD models

observed vs population/individual predictions residuals vs time and predictions visual predictive check ideas

Simulating dosing regimens and clinical scenarios

typical vs extreme patients dose and interval exploration exposure and response bands

Session 4

Fee: Rs 18800

Mini Capstone: PopPK–PD Case & Dosing

Select a PopPK–PD example and summarize model insights

describe structural model and parameters summarize variability and covariate effects highlight key exposure response findings

Translate PopPK–PD results into practical dosing guidance

dose bands for typical and high risk groups monitoring and safety considerations scenarios for future data collection

Deliverables: PopPK–PD case slide deck and one page summary

PDF or PPTX ready for MIDD or PMx meetings template for future PopPK projects

PDF

Population PK/PD — Nonlinear Mixed Effects Modeling Training | PopPK Concepts, NLME & Dosing

Population PK/PD — Nonlinear Mixed Effects Modeling — Hands-on