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Precision Dosing in Renal, Hepatic & Pediatric Care Training | Special Population Dose Adjustment

NTHRYS >> Services >> Academic Services >> Training Programs >> Bioinformatics Training >> Pharmacogenomics, Pharmacometrics & Precision Therapeutics >> Precision Dosing in Renal, Hepatic & Pediatric Care Training | Special Population Dose Adjustment

Precision Dosing in Renal, Hepatic & Pediatric Care — Hands-on

Build a strong conceptual framework for precision dosing in special populations. This module focuses on how renal function, hepatic impairment and growth or maturation in children influence drug exposure, and how to combine PK principles, organ function markers and clinical reasoning to adjust doses safely.

Precision Dosing in Renal, Hepatic & Pediatric Care
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Session 1
Fee: Rs 8800
Foundations of Precision Dosing & Special Populations
  • Why precision dosing matters for vulnerable groups
  • narrow therapeutic index medicines toxicity and under exposure risks variability in PK and PD across patients
  • Key PK concepts for dose adjustment (conceptual)
  • clearance, volume, half life themes maintenance vs loading dose ideas time to steady state intuitions
  • Framework for thinking about special populations
  • organ function and maturation co medication and comorbidities clinical context and risk balance
Session 2
Fee: Rs 11800
Renal Impairment: Concepts & Dose Adjustment
  • Renal handling of drugs and PK consequences
  • filtration, secretion, reabsorption themes changes in clearance in kidney disease accumulation and toxicity risk
  • Markers of kidney function and staging (high level)
  • creatinine based estimates conceptually glomerular filtration rate categories dialysis and residual function ideas
  • Thinking through renal dose adjustment steps
  • assess how much renal route matters reduce dose vs extend interval themes monitoring levels and clinical response
Session 3
Fee: Rs 14800
Hepatic Impairment & Complex Comorbidities
  • Hepatic metabolism, transport and PK implications
  • phase one and phase two pathways idea high extraction vs low extraction drugs protein binding and biliary excretion themes
  • Markers and staging of liver disease (conceptual)
  • laboratory markers and clinical scores idea impact on drug disposition and safety when to avoid or use with caution themes
  • Handling overlapping renal, hepatic and other comorbidities
  • stepwise risk assessment and prioritization simplified dose bands for practice role of therapeutic drug monitoring conceptually
Session 4
Fee: Rs 18800
Pediatric Dosing & Integrated Case Workshop
  • Principles of pediatric dosing and maturation
  • weight and surface area based concepts ontogeny of organ function ideas adherence and formulation considerations
  • Bringing renal, hepatic and pediatric themes together
  • case style dose adjustment reasoning communication of dose changes to teams defining monitoring and follow up plans
  • Deliverables: precision dosing case note and slide summary
  • structured written recommendation one slide visual for teaching rounds template for future special population cases


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