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Real-World Evidence & Observational Data Analytics | Cohorts, Causal Inference & Reporting

NTHRYS >> Services >> Academic Services >> Training Programs >> Bioinformatics Training >> Clinical & Translational Bioinformatics / Precision Medicine >> Real-World Evidence & Observational Data Analytics | Cohorts, Causal Inference & Reporting

Real-World Evidence & Observational Data Analytics — Hands-on

Design and execute robust Real-World Evidence (RWE) studies using clinical registries, claims, and EHR data. This hands-on module covers observational study designs, cohort construction, bias mitigation, causal inference, time-to-event modeling, safety signal detection, and audit-ready reporting aligned to payer and regulatory expectations.

Real-World Evidence & Observational Data Analytics
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Session 1
Fee: Rs 20720
RWE Designs & Data Sources
  • Observational designs
  • cohort/case–control/case-crossover registries & pragmatic trials new-user designs
  • Data sources & standards
  • EHR/claims/registries OMOP (overview) coding (ICD/SNOMED/LOINC/RxNorm)
  • Data quality & missingness
  • completeness & plausibility checks MCAR/MAR/MNAR strategies linkage pitfalls
Session 2
Fee: Rs 24920
Cohorts, Bias & Confounding Control
  • Cohort building & indexing
  • eligibility & washout exposure/outcome windows time-at-risk
  • Bias taxonomy & diagnostics
  • confounding/immortal time channeling/selection negative controls
  • Adjustment strategies
  • propensity scores (PSM/IPTW/OW) DAGs & covariate selection doubly robust methods
Session 3
Fee: Rs 29120
Outcomes, Survival & Causal Inference
  • Endpoints & estimands
  • effectiveness/safety/utilization estimand framework (ICEs) composite outcomes
  • Time-to-event & longitudinal models
  • Kaplan–Meier/Cox/competing risks time-varying exposures mixed models/GEE
  • Causal inference toolkit
  • target trial emulation IVs/diff-in-diff synthetic controls
Session 4
Fee: Rs 34720
Safety Signals, Reporting & Governance
  • Signal detection & monitoring
  • disproportionality (PRR/ROR) sequential monitoring negative/positive controls
  • Transparent reporting
  • STROBE/RECORD effect sizes & CIs sensitivity analyses
  • Governance & compliance (overview)
  • privacy & de-identification data use agreements audit trails & reproducibility


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