RNA Structure & RNA–Protein Complex Modelling — Hands-on

Understand how RNA folds into functional secondary and tertiary structures and how it engages proteins in regulatory and catalytic complexes. This module walks through RNA structure concepts, 2D/3D modelling ideas, RNA–protein interface logic and RNP complex modelling with clear, project-ready reporting.

RNA Structure & RNA–Protein Complex Modelling

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Session Index

Session 1 — RNA Structure Fundamentals & Secondary Folds Session 2 — RNA Motifs, 3D Geometry & Modelling Concepts Session 3 — RNA–Protein Interfaces & Complex Organisation Session 4 — RNP Modelling Mini-Project & Reporting

Session 1

Fee: Rs 27800

RNA Structure Fundamentals & Secondary Folds

RNA chemistry, base pairing and secondary structure

Watson–Crick & non-canonical pairs hairpins, internal/bulge loops, junctions pseudoknot concepts

Representing RNA secondary structure

dot–bracket notation secondary structure diagrams sequence–structure alignment ideas

Secondary structure prediction concepts

thermodynamic vs comparative approaches minimum free energy vs ensemble views base-pair probability and covariation ideas

Session 2

Fee: Rs 31800

RNA Motifs, 3D Geometry & Modelling Concepts

RNA 3D building blocks and motifs

A-form helices and bends kink-turns, tetraloops and internal-loop motifs long-range tertiary contacts concepts

RNA 3D geometry and validation ideas

backbone torsions and sugar puckers base stacking and triplets common geometric outliers

Concepts in RNA 3D modelling

fragment and motif-based assembly ideas using secondary structures as constraints coarse-grained vs atomistic models

Session 3

Fee: Rs 35800

RNA–Protein Interfaces & Complex Organisation

Principles of RNA–protein recognition

RNA-binding domains and motifs concepts sequence vs shape readout electrostatics and stacking contributions

Characterising RNA–protein interfaces on structures

contact residues and interface footprints H-bonds, stacking and salt bridges hotspot and specificity determinants

RNP complex organisation concepts

multi-protein and multi-RNA assemblies modular vs cooperative binding linking structure to function and regulation

Session 4

Fee: Rs 38800

RNP Modelling Mini-Project & Reporting

Mini-project: model an RNA or RNP system conceptually

define sequence and structural questions combine secondary and tertiary reasoning outline interface and binding hypotheses

Narratives, figures and tables for RNA/RNP projects

secondary and 3D structure panels interface maps and motif diagrams cartoons linking structure to function

Deliverables: RNA/RNP structure report & design suggestions

structured summary of structural insights hypotheses for mutations or truncations experiment- and project-ready narrative

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RNA Structure & RNA–Protein Complex Modelling Training | RNA Folds, Interfaces & RNP Projects

RNA Structure & RNA–Protein Complex Modelling — Hands-on