Somatic Variant Analysis in Oncology — Hands-on

Develop practical skills for somatic variant analysis in oncology, from tumor-normal pipelines and FFPE aware QC to mutational signatures and clinical actionability tiers. This module focuses on how bioinformatics outputs connect to real oncology decision making, tumor boards and targeted therapy selection.

Somatic Variant Analysis in Oncology

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Session Index

Session 1 — Tumor Samples, Study Designs & Data Types Session 2 — Tumor-Normal Pipelines & Somatic Calling Session 3 — Filtering, Clonality & Actionability Tiers Session 4 — Mini Capstone: Oncology Case & Variant Table

Session 1

Fee: Rs 8800

Tumor Samples, Study Designs & Data Types

Oncology genomics use cases and indications

solid tumors hematological malignancies liquid biopsy overview

Tumor samples and practical constraints

FFPE vs fresh frozen tumor purity and cellularity normal tissue sources

Panels, exomes and genomes for oncology

targeted hotspot panels comprehensive cancer exomes whole genome tumor profiling

Session 2

Fee: Rs 11800

Tumor-Normal Pipelines & Somatic Calling

Tumor-only vs tumor-normal study designs

pros and cons germline contamination background models

Somatic variant calling concepts

SNVs and indels copy number and LOH snapshot structural alterations overview

FFPE artefacts and noise sources

deamination patterns oxidative damage technical vs biological signals

Session 3

Fee: Rs 14800

Filtering, Clonality & Actionability Tiers

Somatic VCF QC and filtering logic

variant allele fraction depth and mapping quality panel of normals usage

Clonality and tumor evolution snapshot

truncal vs subclonal variants copy number context implications for resistance

Actionability frameworks and tiers

OncoKB style tiers therapy, trial and diagnostic markers tumor type specific vs agnostic

Session 4

Fee: Rs 18800

Mini Capstone: Oncology Case & Variant Table

Work through an oncology somatic case

Theory + Practical

Build a clinical variant summary table

gene and variant evidence and references actionability tier and notes

Prepare tumor board ready snapshot

one page summary key flags and cautions follow up testing suggestions

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Somatic Variant Analysis in Oncology Training | Tumor-Normal Pipelines, Clonality & Actionability

Somatic Variant Analysis in Oncology — Hands-on