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Somatic Variant Interpretation & Actionability (OncoKB/CIViC) | Tiers, Evidence & Reporting

NTHRYS >> Services >> Academic Services >> Training Programs >> Bioinformatics Training >> Clinical & Translational Bioinformatics / Precision Medicine >> Somatic Variant Interpretation & Actionability (OncoKB/CIViC) | Tiers, Evidence & Reporting

Somatic Variant Interpretation & Actionability (OncoKB/CIViC) — Hands-on

Turn somatic variant calls into clear, clinically actionable insights. This module trains you to apply AMP/ASCO/CAP and ESCAT tiering, leverage knowledge bases (OncoKB/CIViC) , synthesize therapy, diagnostic and prognostic evidence, and communicate findings for tumor boards and clinician-facing reports.

Somatic Variant Interpretation & Actionability (OncoKB/CIViC)
Help Desk · WhatsApp
Session 1
Fee: Rs 16520
Frameworks, Tiers & Evidence
  • Guidelines & tiering
    • AMP/ASCO/CAP ESCAT (ESMO) evidence levels
  • Evidence appraisal
    • therapeutic/diagnostic/prognostic trial phases tumor type specificity
  • Nomenclature & harmonization
    • HGVS & transcript choices oncogenicity tags variant groups
Session 2
Fee: Rs 20720
Using OncoKB/CIViC in Practice
  • Curation workflows
    • KB lookups & citations conflict reconciliation audit trails
  • Tiering & evidence calls
    • tumor-specific vs agnostic line of therapy regulatory status (high-level)
  • Automation & pipelines
    • annotation (VEP/OncoKB API) filters & overrides template snippets
Session 3
Fee: Rs 24920
Biomarkers, Resistance & Context
  • Global biomarkers
    • TMB/MSI (overview) HRD & LOH (high-level) fusion drivers
  • Co-occurrence & resistance
    • primary vs secondary subclonality/VAF tumor heterogeneity
  • Tumor type & line-of-therapy context
    • FDA/EMA labels (non-promotional) trial-matching signals contraindications
Session 4
Fee: Rs 30520
Reporting, Tumor Boards & QA
  • Report templates & language
    • tiers & evidence statements limitations/uncertainties citations & versioning
  • Tumor board communication
    • case summaries discussion points follow-up items
  • QA, governance & audits
    • SOPs & change control curation logs re-analysis cadence


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