Systems Pharmacology & PK/PD Integration — Hands-on

Connect pharmacokinetics (PK) , pharmacodynamics (PD) and systems biology. This module introduces systems pharmacology concepts, PK/PD modeling workflows and how to link drug exposure to pathway and phenotype level responses for preclinical and translational research questions.

Systems Pharmacology & PK/PD Integration

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Session Index

Session 1 — PK/PD Foundations & Systems Pharmacology Session 2 — PK Models, Compartments & Dose Regimens Session 3 — PD Models, Exposure–Response & Pathways Session 4 — Mini Capstone: PK/PD & Systems Pharmacology Case

Session 1

Fee: Rs 8800

PK/PD Foundations & Systems Pharmacology

What PK, PD and systems pharmacology cover

ADME and exposure concepts effect and response ideas pathway and network context

Use cases in preclinical and translational research

dose and schedule exploration combination strategy ideas linking biomarkers to models

Modeling ingredients and data types

concentration time profiles effect and biomarker time series covariates and variability view

Session 2

Fee: Rs 11800

PK Models, Compartments & Dose Regimens

Compartment models and ADME intuition

one and two compartment ideas clearance and volume concepts distribution and elimination views

Dosing routes and regimens (conceptual)

bolus vs infusion sketches oral dosing and absorption idea multiple dose accumulation view

PK parameters and summary metrics

Cmax, AUC and half life intuition exposure windows and thresholds steady state concepts

Session 3

Fee: Rs 14800

PD Models, Exposure–Response & Pathways

Direct and indirect response model ideas

Emax and sigmoid Emax intuition delayed effects and turnover view link models between PK and PD

Exposure–response and variability awareness

concentration effect plots inter individual variability concept safety and efficacy windows view

Systems pharmacology and pathways

placing PK/PD into networks multi target and pathway effects combination and sequence concepts

Session 4

Fee: Rs 18800

Mini Capstone: PK/PD & Systems Pharmacology Case

Pick a small PK/PD and systems pharmacology scenario

theory plus guided practical

Sketch PK and PD models and explore dose scenarios

simple compartment PK sketch Emax or indirect response PD compare a few regimens conceptually

Deliverables: notebook, diagrams and short summary

Python or R notebook PK/PD block diagrams PDF or HTML case summary

PDF

Systems Pharmacology and PK/PD Integration Training | Linking Exposure, Response & Pathways

Systems Pharmacology & PK/PD Integration — Hands-on