Target Annotation Chemogenomics & Off-Target Mining — Hands-on

Develop practical skills in target annotation and chemogenomics so that you can connect targets to ligands, pathways and off target risk. This module focuses on using public and project data to build target views, chemogenomic maps and off target liability panels that feed into discovery and safety aware decision making.

Target Annotation Chemogenomics & Off Target Mining

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Session Index

Session 1 — Target Annotation & Data Foundations Session 2 — Chemogenomics & Target Space Mapping Session 3 — Off Target Mining & Liability Panels Session 4 — Mini Capstone: Target & Off Target Dossier

Session 1

Fee: Rs 8800

Target Annotation & Data Foundations

Target annotation concepts and minimal data package

target classes and families disease biology and pathway links expression and tissue context views

Data sources for targets and bioactivity

UniProt, ChEMBL, PubChem style resources assay and bioactivity tables integrating public and in house data

Cleaning, normalizing and summarizing target data

unit conversion and direction of potency handling multiple assays and conditions simple potency summaries and flags

Session 2

Fee: Rs 11800

Chemogenomics & Target Space Mapping

Chemogenomics principles and target ligand matrices

linking targets, ligands and assays target similarity and family views ligand centric vs target centric perspectives

Visualizing chemogenomic space for a project

heatmaps and network diagrams clustered target ligand maps highlighting gaps and opportunities

Simple target panels and selectivity landscapes

core and extended panel ideas selectivity profiles across families tying target space to project strategy

Session 3

Fee: Rs 14800

Off Target Mining & Liability Panels

Definitions and patterns of off target and polypharmacology

beneficial vs harmful polypharmacology safety relevant target classes clinical liability examples at a high level

Mining off targets from bioactivity and similarity data

ligand based target prediction concepts similarity and profile based lookups network based off target hints

Constructing simple off target and safety panels

cardiac, CNS and other liability panels traffic light and scorecard views communication to project and safety teams

Session 4

Fee: Rs 18800

Mini Capstone: Target & Off Target Dossier

Building a compact target and chemogenomics dossier

Theory + Practical

Creating an off target and safety panel summary

panel selection and rationale traffic light and score tables simple risk narrative for chemists

Deliverables: target and off target report for project teams

notebook or script for data pulls figures and panel tables two to three slide summary deck

PDF

Target Annotation, Chemogenomics & Off-Target Mining Training | Target Space, Panels & Liabilities

Target Annotation Chemogenomics & Off-Target Mining — Hands-on