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Biotechnology Internship Topics

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Biotechnology Internships with Accommodation

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Showing 85–96 of 111 internship topics
Stability Testing and Shelf-Life Determination
Interns will design and execute accelerated and long-term stability studies on biotechnology products under various environmental conditions. They will analyze chemical and physical degradation patterns, establish shelf-life predictions, and ensure product efficacy and safety throughout its intended storage period.
Quality Control and Analytical TestingView internship →
Residual Analysis and Impurity Detection
Interns will develop analytical methods to detect and quantify residual contaminants such as endotoxins, DNA, host cell proteins, and process-related impurities in biologics. They will establish acceptance criteria and perform risk assessments to ensure product safety and quality standards.
Quality Control and Analytical TestingView internship →
High-Throughput Protein Library Construction and Screening
Interns will learn techniques for creating large combinatorial protein libraries using phage display, yeast display, or ribosome display technologies. They will develop skills in library construction, validation, and implementation of selection rounds to identify variants with desired properties such as improved binding affinity or catalytic efficiency.
Directed Evolution and Protein ScreeningView internship →
Directed Evolution of Enzymes for Biocatalysis
Interns will apply iterative mutagenesis and selection strategies to engineer enzymes with enhanced activity, substrate specificity, or stability for industrial applications. They will perform functional assays, analyze sequence data, and characterize improved enzyme variants through kinetic studies and structural analysis.
Directed Evolution and Protein ScreeningView internship →
Cell-Free Protein Expression and In Vitro Compartmentalization
Interns will utilize cell-free systems and water-in-oil emulsions to link genotype-phenotype relationships for screening large libraries without cellular constraints. They will optimize expression conditions, develop compartmentalization protocols, and apply these systems to evolve proteins with novel or enhanced functions.
Directed Evolution and Protein ScreeningView internship →
Machine Learning Applications in Protein Sequence Analysis and Design
Interns will integrate computational tools and machine learning models to predict protein properties, guide mutagenesis strategies, and optimize screening campaigns. They will analyze deep mutational scanning data, develop predictive models for fitness landscapes, and support rational protein design efforts.
Directed Evolution and Protein ScreeningView internship →
Antibody Engineering and Affinity Maturation
Interns will participate in projects focused on optimizing antibody therapeutics through directed evolution techniques including yeast display and phage display. They will work on binding kinetics improvement, specificity enhancement, and stability optimization while learning characterization methods such as ELISA and surface plasmon resonance.
Directed Evolution and Protein ScreeningView internship →
Cryo-EM Sample Preparation and Grid Optimization
Interns will learn and practice sample preparation techniques for cryo-electron microscopy, including protein concentration optimization, grid glow discharge, plunge-freezing procedures, and quality assessment of vitreous ice. They will troubleshoot common issues in sample preparation and optimize parameters to improve particle distribution and ice thickness for high-resolution imaging.
Structural Biology and Cryo-EM ResearchView internship →
3D Reconstruction and Image Processing Pipeline Development
Interns will work with cryo-EM image datasets to perform 2D classification, 3D reconstruction, and refinement using software tools such as RELION, cryoSPARC, or Frealign. They will learn computational methods for noise reduction, resolution optimization, and validation of structural models through iterative processing workflows.
Structural Biology and Cryo-EM ResearchView internship →
Protein Structure Modeling and Molecular Dynamics Simulation
Interns will utilize cryo-EM density maps to build atomic models using tools like Coot and Phenix, and perform molecular dynamics simulations to validate structural integrity and study protein dynamics. They will analyze protein-ligand interactions, conformational changes, and functional mechanisms based on structural data.
Structural Biology and Cryo-EM ResearchView internship →
Cryo-EM Instrument Operation and Data Acquisition
Interns will receive hands-on training in operating transmission electron microscopes equipped with direct detectors, including sample loading, microscope calibration, and automated data collection protocols. They will learn microscopy principles, detector specifications, and best practices for acquiring high-quality micrographs for structural analysis.
Structural Biology and Cryo-EM ResearchView internship →
Structural Comparison and Homology Modeling in Drug Discovery
Interns will analyze cryo-EM structures of drug targets and perform comparative structural analysis with homologous proteins to identify binding pockets and druggable sites. They will conduct homology modeling, docking studies, and structure-activity relationship analyses to support rational drug design and biomarker discovery.
Structural Biology and Cryo-EM ResearchView internship →
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