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Molecular Cancer Research Internship Topics

Browse all focused areas across all internship categories under this field.

Molecular Cancer Research Internships with Accommodation

Choose an internship topic, then explore accommodation-enabled internship options at active NTHRYS branch locations in India.

Showing 1–12 of 15 internship topics
Chromatin Remodeling Complex Characterization
Interns will investigate the structural and functional properties of ATP-dependent chromatin remodeling complexes (SWI/SNF, ISWI, CHD, INO80 families) in cancer cells. Work includes protein purification, co-immunoprecipitation assays, and biochemical characterization of complex assembly and activity. This research directly contributes to understanding how cancer cells exploit chromatin remodeling for oncogenic transformation.
Chromatin Remodeling Cancer EpigeneticsView internship →
Histone Modification Profiling in Cancer Genomes
Interns will perform ChIP-seq and CUT&RUN experiments to map histone modifications (H3K4me3, H3K27me3, H3K9ac) across cancer cell genomes and correlate these patterns with gene expression and tumor phenotypes. Data analysis includes peak calling, differential binding analysis, and integration with RNA-seq data to identify epigenetic drivers of cancer progression.
Chromatin Remodeling Cancer EpigeneticsView internship →
Cancer-Associated Epigenetic Mutations and Chromatin Dysfunction
Interns will study recurrent mutations in chromatin remodeling genes (ARID1A, PBRM1, BAP1) and histone modifiers found in various cancer types using bioinformatics and functional validation approaches. This includes analyzing mutation databases, performing structural modeling, and conducting functional assays to determine how these mutations compromise chromatin homeostasis and promote tumorigenesis.
Chromatin Remodeling Cancer EpigeneticsView internship →
Polycomb Repressive Complex Function in Cancer Stem Cells
Interns will investigate the role of Polycomb Repressive Complexes (PRC1 and PRC2) in maintaining cancer stem cell identity and self-renewal capacity. Experimental work includes CRISPR/Cas9-mediated knockdown of PRC components, single-cell RNA-seq analysis, and functional assays measuring stemness markers and differentiation capacity in cancer cell models.
Chromatin Remodeling Cancer EpigeneticsView internship →
Epigenetic Plasticity and Treatment Resistance in Cancer
Interns will examine how cancer cells utilize chromatin remodeling and histone modifications to escape therapeutic pressure and develop drug resistance. Research includes analyzing chromatin dynamics before and after chemotherapy/targeted therapy using live-cell imaging and multi-omics approaches, and identifying chromatin-based vulnerabilities for overcoming treatment resistance.
Chromatin Remodeling Cancer EpigeneticsView internship →
3D Tumor Organoid Culture and Characterization
Interns will learn to establish and maintain 3D cancer organoid cultures from patient-derived tissues or cancer cell lines, including techniques for scaffold-based and scaffold-free culture systems. They will perform characterization studies using histology, immunofluorescence, and gene expression analysis to validate organoid authenticity and tumor heterogeneity.
Organoid Development Cancer Biology ModelsView internship →
Drug Response Testing in Cancer Organoids
Interns will conduct high-throughput drug screening assays on established cancer organoids to evaluate chemotherapy and targeted drug efficacy, measuring viability, apoptosis, and drug resistance mechanisms. This work bridges preclinical modeling with potential personalized medicine applications.
Organoid Development Cancer Biology ModelsView internship →
Organoid-Derived Extracellular Matrix and Microenvironment Engineering
Interns will investigate the role of the tumor microenvironment in organoid development by manipulating extracellular matrix components, growth factors, and stromal cell interactions. They will assess how microenvironmental modifications influence cancer cell behavior, differentiation, and therapeutic response.
Organoid Development Cancer Biology ModelsView internship →
Single-Cell Analysis and Transcriptomics in Cancer Organoids
Interns will apply single-cell RNA sequencing and flow cytometry techniques to dissect cellular heterogeneity within cancer organoids and identify distinct cancer cell populations. This work enables characterization of tumor evolution, clonal dynamics, and identification of cancer stem cell populations.
Organoid Development Cancer Biology ModelsView internship →
Patient-Derived Xenograft (PDX) Organoid Development and Modeling
Interns will derive organoids from patient tumor tissues and establish patient-derived models that maintain genetic and phenotypic features of original cancers. They will validate organoid fidelity through genomic profiling and correlate organoid drug responses with patient clinical outcomes.
Organoid Development Cancer Biology ModelsView internship →
Synthesis and Characterization of Polymeric Nanoparticles
Interns will learn techniques for synthesizing polymeric nanoparticles (liposomes, micelles, dendrimers) using methods like emulsion polymerization and self-assembly. They will characterize particle size, zeta potential, morphology, and stability using DLS, TEM, and UV-Vis spectroscopy to optimize formulations for drug delivery applications.
Nanoparticle Drug Delivery Cancer TreatmentView internship →
Drug Loading and Release Kinetics Studies
Interns will investigate methods for loading chemotherapeutic agents onto nanoparticles and analyze their release profiles under physiological conditions using HPLC and fluorescence spectroscopy. They will study factors affecting drug bioavailability, including pH-responsiveness and stimuli-triggered release mechanisms.
Nanoparticle Drug Delivery Cancer TreatmentView internship →
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