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Molecular Biology Internship Topics

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Molecular Biology Internships with Accommodation

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Showing 133–144 of 155 internship topics
Laminin Isoform Characterization and Cell Recognition
Interns will characterize different laminin isoforms and their specific interactions with cell surface receptors, particularly dystroglycan and integrins. This includes expression profiling, protein purification, and functional assays to determine tissue-specific binding preferences and biological outcomes.
Extracellular Matrix Protein Interaction StudyView internship →
Matrix Metalloproteinase-ECM Substrate Specificity
Interns will examine how different MMPs recognize and cleave extracellular matrix proteins including collagen, gelatin, and fibronectin using substrate assays and molecular modeling. This research explores the structural determinants of protease specificity and implications for tissue remodeling and disease.
Extracellular Matrix Protein Interaction StudyView internship →
Fibronectin Conformational Changes and Mechanotransduction
Interns will investigate how fibronectin undergoes conformational changes upon cell binding and mechanical stress using atomic force microscopy, fluorescence microscopy, and biochemical assays. This work elucidates the relationship between ECM protein structure and cellular signaling responses.
Extracellular Matrix Protein Interaction StudyView internship →
RNA-Seq Read Alignment and Quality Control
Interns will learn to preprocess raw sequencing data, perform quality assessment using FastQC, and align reads to reference genomes using tools like HISAT2 or BWA. They will gain practical experience in identifying and handling low-quality samples, adapter contamination, and generating alignment metrics reports.
Transcriptomics RNA-Seq Data AnalysisView internship →
Differential Gene Expression Analysis
Interns will analyze aligned RNA-Seq data to identify differentially expressed genes between experimental conditions using statistical packages like DESeq2 or edgeR. They will perform normalization, statistical testing, and generate visualization outputs including volcano plots and heatmaps.
Transcriptomics RNA-Seq Data AnalysisView internship →
Gene Annotation and Functional Enrichment Analysis
Interns will annotate identified genes and perform pathway enrichment analysis using databases like KEGG, GO, and Reactome to interpret biological significance. They will learn functional annotation tools and create comprehensive reports linking transcriptomic findings to biological processes.
Transcriptomics RNA-Seq Data AnalysisView internship →
Single-Cell RNA-Seq Data Processing and Cell Clustering
Interns will work with scRNA-Seq datasets to perform quality control, normalization, dimensionality reduction (PCA, t-SNE, UMAP), and unsupervised clustering to identify distinct cell populations. They will learn specialized tools like Seurat or Scanpy for single-cell analysis workflows.
Transcriptomics RNA-Seq Data AnalysisView internship →
RNA-Seq Visualization and Data Integration
Interns will create publication-quality visualizations of transcriptomic data and integrate multiple RNA-Seq datasets for meta-analysis or comparative studies. They will develop skills in using R/Python packages for advanced plotting, batch effect correction, and multi-omics data integration.
Transcriptomics RNA-Seq Data AnalysisView internship →
Caspase Activation and Signaling Cascades
Interns will investigate the molecular mechanisms of initiator and executioner caspase activation in apoptotic pathways. They will perform biochemical assays, Western blotting, and fluorescent substrate analysis to measure caspase activity and study their role in proteolytic cleavage of downstream targets.
Apoptosis Programmed Cell Death PathwaysView internship →
Mitochondrial Outer Membrane Permeabilization (MOMP)
Interns will examine the intrinsic apoptotic pathway by studying Bcl-2 family proteins and their regulation of MOMP. Projects will include protein-protein interaction studies, cell fractionation experiments, and assessment of cytochrome c release using fluorescence microscopy and flow cytometry.
Apoptosis Programmed Cell Death PathwaysView internship →
Death Receptor-Mediated Extrinsic Pathways
Interns will analyze the extrinsic apoptotic pathway through death receptor signaling (Fas, TNF-R, TRAIL-R). They will design experiments involving ligand-receptor binding, DISC (Death-Inducing Signaling Complex) formation analysis, and real-time measurement of apoptotic responses in cell culture models.
Apoptosis Programmed Cell Death PathwaysView internship →
p53-Dependent Apoptosis and Stress Response
Interns will explore the tumor suppressor p53's role in triggering apoptosis under cellular stress conditions. Research will involve studying p53 stabilization, DNA damage response pathways, and transcriptional regulation of pro-apoptotic genes through qPCR and ChIP-seq analysis.
Apoptosis Programmed Cell Death PathwaysView internship →
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