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Molecular Biology Internship Topics

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Molecular Biology Internships with Accommodation

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Showing 25–36 of 155 internship topics
Systems Biology Modeling of Signal Transduction Networks
Interns will construct computational models of cellular signaling networks using graph neural networks and systems biology tools. They will simulate pathway dynamics, predict system responses to perturbations, and integrate multi-omics data to understand cross-talk between signaling cascades.
AI Cell Signaling Molecular ResearchView internship →
Machine Learning Model Development for Protein-DNA Binding Prediction
Interns will develop and train neural network models to predict binding affinities and interaction sites between proteins and DNA sequences. They will work with datasets like PDBbind and create validation pipelines to evaluate model performance against experimental benchmarks.
AI Protein-DNA Interaction ResearchView internship →
Structural Bioinformatics and Molecular Docking Studies
Interns will conduct computational docking simulations using tools like AutoDock and HADDOCK to analyze protein-DNA complex structures. They will perform molecular dynamics simulations to understand binding mechanisms and protein-DNA recognition patterns in silico.
AI Protein-DNA Interaction ResearchView internship →
Sequence Analysis and Motif Discovery in Transcription Factor Binding
Interns will analyze genomic sequences to identify and characterize DNA binding motifs recognized by transcription factors using bioinformatics tools like MEME and JASPAR. They will correlate sequence patterns with experimental binding data to understand specificity determinants.
AI Protein-DNA Interaction ResearchView internship →
Deep Learning for ChIP-seq Data Analysis and Peak Prediction
Interns will apply convolutional neural networks and other deep learning approaches to analyze ChIP-seq datasets for identifying protein-DNA interaction peaks. They will develop models to predict novel binding sites and validate findings against wet-lab experimental results.
AI Protein-DNA Interaction ResearchView internship →
Comparative Genomics of DNA-Binding Proteins Across Species
Interns will perform computational comparative analysis of protein-DNA interaction patterns across different organisms using sequence alignment and phylogenetic tools. They will investigate evolutionary conservation of binding sites and functional implications across species to understand interaction evolution.
AI Protein-DNA Interaction ResearchView internship →
CRISPR-Cas9 Off-Target Effects Analysis
Interns will investigate and characterize unintended genomic modifications resulting from CRISPR-Cas9 targeting. They will utilize bioinformatics tools and sequencing data to identify off-target sites, analyze their functional consequences, and develop strategies to minimize off-target activity through guide RNA optimization.
CRISPR Gene Editing Mechanism ResearchView internship →
PAM Sequence Engineering and Specificity
Interns will explore protospacer adjacent motif (PAM) recognition mechanisms and engineer novel PAM sequences to expand CRISPR targeting capabilities. This work involves molecular modeling, in vitro validation, and comparative analysis of different Cas9 variants with altered PAM specificities.
CRISPR Gene Editing Mechanism ResearchView internship →
Base and Prime Editing Optimization
Interns will work on developing and optimizing base editing and prime editing approaches as alternatives to conventional CRISPR knockouts. They will conduct experiments to improve editing efficiency, reduce undesired byproducts, and establish protocols for precise nucleotide conversions without double-strand breaks.
CRISPR Gene Editing Mechanism ResearchView internship →
CRISPR Delivery System Development
Interns will investigate viral and non-viral delivery methods for CRISPR components into target cells and tissues. This includes optimizing nanoparticle formulations, evaluating transfection efficiency, assessing cellular uptake mechanisms, and testing in vivo delivery efficacy in model organisms.
CRISPR Gene Editing Mechanism ResearchView internship →
Multiplexed CRISPR Array Design and Validation
Interns will design and validate multiplexed CRISPR systems capable of simultaneously editing multiple genomic targets. They will work on optimizing guide RNA arrays, testing simultaneous multi-gene knockouts, and analyzing potential interactions between parallel editing events in mammalian cells.
CRISPR Gene Editing Mechanism ResearchView internship →
Adeno-Associated Virus (AAV) Capsid Engineering
Interns will work on designing and characterizing engineered AAV variants with improved tissue tropism and reduced immunogenicity. This involves directed evolution techniques, serotype screening, and computational modeling to develop safer and more efficient vectors for therapeutic applications.
Gene Therapy Vector Development ResearchView internship →
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