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Molecular Biology Internship Topics

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Molecular Biology Internships with Accommodation

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Showing 49–60 of 155 internship topics
Epigenetic Markers: DNA Methylation and Histone Modifications
Interns will explore epigenetic alterations including DNA methylation patterns and histone modifications that serve as cancer biomarkers. They will use techniques like bisulfite sequencing and ChIP-seq to correlate epigenetic changes with cancer phenotypes.
Molecular Marker Discovery Cancer ResearchView internship →
Liquid Biopsy Marker Discovery from Circulating Tumor DNA and Exosomes
Interns will develop and optimize methods to detect and analyze circulating tumor DNA (ctDNA) and exosomal markers in blood samples as non-invasive cancer biomarkers. This includes establishing protocols for isolation, sequencing, and validation of these liquid biopsy markers.
Molecular Marker Discovery Cancer ResearchView internship →
Michaelis-Menten Kinetics Parameter Determination
Interns will design and execute enzyme kinetics experiments to determine key parameters (Km, Vmax, kcat) for target enzymes using steady-state kinetics methods. They will perform initial velocity studies, generate Lineweaver-Burk and Eadie-Hofstee plots, and analyze data using non-linear regression to characterize enzyme efficiency and substrate specificity.
Enzyme Kinetics Optimization Laboratory StudyView internship →
Enzyme Inhibition Mechanism Characterization
Interns will investigate competitive, non-competitive, and uncompetitive inhibition patterns through systematic kinetic studies with known inhibitors. They will determine inhibition constants (Ki) and elucidate inhibitor binding mechanisms using double reciprocal plots and enzyme kinetics modeling software.
Enzyme Kinetics Optimization Laboratory StudyView internship →
Protein Expression and Purification Optimization
Interns will optimize recombinant enzyme production through manipulation of expression conditions, cell culture parameters, and purification protocols including affinity chromatography and gel electrophoresis. They will assess protein yield, purity, and activity to establish efficient workflows for downstream kinetics studies.
Enzyme Kinetics Optimization Laboratory StudyView internship →
Temperature and pH Effect Analysis on Enzyme Activity
Interns will systematically evaluate how environmental variables affect enzyme catalytic efficiency through temperature gradient studies and pH optimization experiments. They will determine activation energy (Ea) using the Arrhenius equation and identify optimal conditions for maximal enzyme performance.
Enzyme Kinetics Optimization Laboratory StudyView internship →
Multi-Substrate Enzyme Kinetics and Mechanism Studies
Interns will investigate complex enzyme systems with multiple substrates using varied substrate concentration experiments to determine reaction order and mechanism (ordered sequential, random, or ping-pong). They will apply advanced kinetic analyses including isothermal titration calorimetry (ITC) to understand substrate binding interactions.
Enzyme Kinetics Optimization Laboratory StudyView internship →
CRISPR-Based Gene Regulation Circuits
Interns will design and construct genetic circuits using CRISPR interference (CRISPRi) and activation (CRISPRa) systems to create programmable gene regulation networks. They will perform computational modeling of circuit behavior, conduct molecular cloning, and validate circuit functionality in bacterial or mammalian cells through quantitative gene expression analysis.
Synthetic Biology Genetic Circuit DesignView internship →
Metabolic Engineering and Biosynthetic Pathways
Interns will work on designing multi-gene metabolic circuits to produce high-value compounds such as biofuels, pharmaceuticals, or specialty chemicals in engineered microorganisms. This includes pathway optimization, enzyme engineering, flux balance analysis, and strain characterization using analytical techniques like HPLC and GC-MS.
Synthetic Biology Genetic Circuit DesignView internship →
Synthetic Oscillators and Temporal Logic Gates
Interns will engineer biological oscillatory systems and temporal logic circuits that can generate time-dependent gene expression patterns or respond to sequential inputs. Work will involve designing repressilator networks or toggle switches, mathematical modeling using ordinary differential equations, and experimental validation through fluorescent protein reporters and time-lapse microscopy.
Synthetic Biology Genetic Circuit DesignView internship →
Cell-Cell Communication and Quorum Sensing Circuits
Interns will develop engineered communication systems between cells using synthetic quorum sensing, cell-to-cell signaling pathways, and receiver-sender cell populations to create coordinated multicellular behaviors. They will design circuit logic, perform co-culture experiments, and analyze population-level responses using flow cytometry and microscopy.
Synthetic Biology Genetic Circuit DesignView internship →
Protein Design and Enzyme Engineering for Circuit Applications
Interns will use computational protein design and directed evolution techniques to engineer novel biosensors, transcription factors, or enzymatic components for integration into genetic circuits. This includes structure-guided design, variant library construction, high-throughput screening, and characterization of binding kinetics and catalytic efficiency.
Synthetic Biology Genetic Circuit DesignView internship →
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