ASCEND BY NTHRYS
Research Abroad Products

Molecular Biology Internship Topics

Browse all focused areas across all internship categories under this field.

Molecular Biology Internships with Accommodation

Choose an internship topic, then explore accommodation-enabled internship options at active NTHRYS branch locations in India.

Showing 61–72 of 155 internship topics
mtDNA Sequencing and Variant Detection
Interns will learn high-throughput sequencing techniques for mitochondrial DNA, including library preparation, next-generation sequencing analysis, and bioinformatic pipelines for identifying point mutations and deletions. They will practice variant calling, annotation, and distinguishing pathogenic mutations from benign polymorphisms.
Mitochondrial DNA Mutation AnalysisView internship →
Heteroplasmy Assessment and Quantification
Interns will investigate methods to measure heteroplasmy levels—the proportion of mutant versus wild-type mtDNA within cells—using techniques like digital PCR, droplet sequencing, and quantitative mass spectrometry. This work explores how heteroplasmy thresholds correlate with mitochondrial disease phenotypes.
Mitochondrial DNA Mutation AnalysisView internship →
mtDNA Mutation Pathogenesis and Functional Analysis
Interns will conduct cell-based and molecular studies to elucidate how specific mtDNA mutations impair mitochondrial function, examining effects on oxidative phosphorylation, ATP production, and reactive oxygen species generation. They may use cell culture models, respirometry assays, and Western blotting to characterize mutation impacts.
Mitochondrial DNA Mutation AnalysisView internship →
Population Genetics and mtDNA Polymorphism Databases
Interns will contribute to building and curating mitochondrial DNA variant databases by analyzing population sequencing data across diverse ethnic backgrounds, identifying novel mutations, and establishing frequencies of known variants. They will develop bioinformatic tools for mtDNA haplogroup classification and phylogenetic analysis.
Mitochondrial DNA Mutation AnalysisView internship →
Clinical Correlation and Disease Phenotyping
Interns will correlate mtDNA mutation profiles with patient clinical presentations in mitochondrial disorders, analyzing medical records, biochemical test results, and genetic data. This involves statistical analysis of genotype-phenotype relationships and case study preparation for research publication.
Mitochondrial DNA Mutation AnalysisView internship →
Bacterial Expression System Optimization
Interns will optimize protein expression in E. coli and other bacterial hosts by manipulating culture conditions, media formulations, and induction strategies. They will work on improving protein yield and solubility through systematic parameter variation and analysis of expression kinetics.
Protein Expression System OptimizationView internship →
Mammalian Cell Culture-Based Protein Production
Interns will develop and scale mammalian expression systems using CHO, HEK293, or other cell lines for producing recombinant proteins and biologics. They will focus on transfection optimization, cell line selection, and bioreactor cultivation techniques to maximize protein titers.
Protein Expression System OptimizationView internship →
Post-Translational Modification Engineering
Interns will investigate methods to enhance post-translational modifications (glycosylation, phosphorylation, disulfide bond formation) in protein expression systems through host strain selection and bioprocess optimization. This work involves characterizing modification patterns and their impact on protein function.
Protein Expression System OptimizationView internship →
Recombinant Protein Purification and Characterization
Interns will develop and optimize purification strategies for expressed proteins using chromatography techniques and analytical methods. They will characterize protein purity, structure, and functionality using SDS-PAGE, mass spectrometry, and biophysical assays.
Protein Expression System OptimizationView internship →
Heterologous Expression in Non-Conventional Hosts
Interns will explore emerging expression systems such as yeast, insect cells, plants, or cell-free systems for producing difficult-to-express proteins. They will evaluate host-specific advantages for producing proteins with improved properties, reduced toxicity, or enhanced post-translational modifications.
Protein Expression System OptimizationView internship →
G1/S Checkpoint Control Mechanisms
Interns will investigate how cyclin-CDK complexes regulate the G1/S transition and control DNA replication initiation. Research will involve studying retinoblastoma protein phosphorylation, E2F transcription factor activation, and checkpoint licensing factors to understand cell cycle progression control.
Cell Cycle Regulation Checkpoint ResearchView internship →
DNA Damage Response and G2/M Checkpoint
Interns will examine how cells detect DNA damage through ATM/ATR pathways and activate G2/M checkpoint mechanisms involving p53 and CHK2 kinases. Practical work will include studying checkpoint recovery, apoptosis induction, and the role of p21 in cell cycle arrest.
Cell Cycle Regulation Checkpoint ResearchView internship →
Want to browse internship categories in Molecular Biology? Explore all Molecular Biology internship categories.