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Molecular Biology Internship Topics

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Molecular Biology Internships with Accommodation

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Showing 97–108 of 155 internship topics
DNMT Enzyme Function and Inhibitor Screening
Interns will conduct experimental studies on DNA methyltransferase (DNMT) enzymes, including expression profiling and activity assays using recombinant proteins. They will perform high-throughput screening of potential DNMT inhibitors and evaluate their effects on methylation dynamics in cultured cell systems.
DNA Methylation Pattern Epigenetic StudyView internship →
Age-Related DNA Methylation Clock Development
Interns will work with longitudinal epigenetic datasets to identify age-associated methylation sites and develop predictive methylation clock models. They will employ machine learning approaches to establish biomarkers for biological age assessment and validate findings across different tissue types.
DNA Methylation Pattern Epigenetic StudyView internship →
Environmental Factor-Induced Epigenetic Modifications
Interns will investigate how environmental exposures (pollutants, diet, stress) alter DNA methylation patterns in model organisms or primary cell cultures using pyrosequencing and qPCR techniques. They will analyze site-specific methylation changes in response genes and establish dose-response relationships.
DNA Methylation Pattern Epigenetic StudyView internship →
Transgenerational Epigenetic Inheritance and DNA Methylation
Interns will study heritable methylation patterns across generations using transgenic models or population-based cohort data, examining parent-of-origin effects on gene methylation. They will investigate replication and erasure of methylation marks during development and identify stable epialleles.
DNA Methylation Pattern Epigenetic StudyView internship →
G Protein-Coupled Receptor (GPCR) Ligand Binding Studies
Interns will investigate ligand-binding mechanisms in GPCRs through molecular docking simulations, site-directed mutagenesis, and binding affinity assays. They will analyze conformational changes induced by different ligands and correlate structural modifications with functional outcomes in signal transduction pathways.
Membrane Protein Structure Function AnalysisView internship →
Ion Channel Electrophysiology and Patch-Clamp Analysis
Interns will conduct patch-clamp electrophysiology experiments to characterize ion channel gating kinetics, selectivity filters, and pore dynamics. They will analyze single-channel recordings, construct ion conductance curves, and investigate how mutations affect channel function and disease phenotypes.
Membrane Protein Structure Function AnalysisView internship →
Transmembrane Protein Topology and Secondary Structure Prediction
Interns will use bioinformatics tools and experimental techniques including circular dichroism spectroscopy to predict and validate transmembrane domain arrangements. They will perform protein sequence alignment analysis, hydropathy plot generation, and cryo-electron microscopy data interpretation to map protein topology.
Membrane Protein Structure Function AnalysisView internship →
Protein-Lipid Interactions and Membrane Dynamics
Interns will investigate how membrane proteins interact with specific lipid compositions using liposome flotation assays, surface plasmon resonance (SPR), and molecular dynamics simulations. They will examine the role of lipid environment in protein stability, localization, and functional regulation.
Membrane Protein Structure Function AnalysisView internship →
Structural Analysis of Transport Proteins and Antiporters
Interns will analyze the transport mechanisms of membrane transporters and antiporters using X-ray crystallography data analysis and cryo-EM structures. They will model substrate-binding events, determine transport kinetics through functional assays, and investigate allosteric regulation mechanisms involved in active and passive transport.
Membrane Protein Structure Function AnalysisView internship →
Bacterial Conjugation Pathway Analysis
Interns will investigate the mechanisms of plasmid transfer between bacterial cells through conjugation, including pili formation, DNA replication, and recipient cell recognition. Students will perform wet-lab experiments involving antibiotic resistance marker tracking and develop computational models to predict conjugation efficiency across different bacterial species.
Horizontal Gene Transfer Microbial StudyView internship →
Metagenomic Sequencing of Environmental Microbial Communities
Interns will collect and analyze environmental samples (soil, water, biofilms) to identify horizontal gene transfer events using next-generation sequencing and bioinformatic tools. They will characterize microbial community composition and track the distribution of acquired genetic elements across different microbial populations.
Horizontal Gene Transfer Microbial StudyView internship →
CRISPR-Cas System Evolution and Transfer Dynamics
Interns will study how CRISPR-Cas defense systems spread horizontally among microbial populations and analyze their evolutionary relationships across diverse bacterial genera. Research will involve phylogenetic reconstruction, comparative genomics, and assessment of spacer sequences to understand viral-bacterial evolutionary arms races.
Horizontal Gene Transfer Microbial StudyView internship →
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